Preclinical Products - Tissue Microscopy and Analyses

Adding Nuance to your lab is a simple, cost-effective means of upgrading your microscope to a powerful multispectral imaging system. Multiplexed labeling can now be achieved while retaining intact morphology, so highly informative spatial information is maintained. The Nuance system enables imaging of multiple molecular markers in tissue sections for both fluorescence and brightfield, even when they are co-localized. Nuance can also eliminate problems stemming from the presence of autofluorescence, and can pull apparently absent signals out of the noise, making them visible and quantitatable. Increase the signal-to-noise of your fluorophores, gaining access to information you can't get any other way.

Compact, affordable and versatile system for image capture of any three chromogens or any three fluorophores in its spectral ranges (see table). Additionally, autofluorescence is removed, increasing signal-to-noise by up to 100x and improving quantitation. TRIO is compatible with any microscope with a camera mount and can take high-resolution color and multispectral images. TRIO has a simple, easy-to-use user interface. No advanced knowledge of multispectral imaging is required. Setup and operation can be accomplished in a matter of minutes.

Extracting meaningful data from intact tissue is becoming ever more critical as researchers look for ways to characterize molecular activity of cells in their native microenvironments. In life sciences research and in pharmaceutical drug development, progress often depends on extracting meaningful data from tissue sections. In translational oncology, data extraction is central to target validation, trial design, patient selection, characterizing efficacy and response, and making correlations with clinical outcome.

Are you performing studies using tissue sections or tissue microarrays? If so then you'll want to consider using Vectra, the most advanced instrument for extracting proteomic and morphometric information from intact tissue sections. Vectra merges automated slide-handling, multispectral imaging technology, and unique pattern-recognition-based image analysis into a powerful system for clinical studies. This system accurately measures protein expressions and morphometric characteristics in distinct tissue regions of interest or on whole slides. Sections can be labeled with either immunofluorescent (IF) or immunohistochemical (IHC) stains, or with conventional stains such as H&E and trichrome. With IF or IHC, single or multiple proteins can be measured on a per-tissue, per-cell, and per-cell-compartment (eg. nuclear, cytoplasmic) basis, even if those signals are spectrally similar, are in the same cell compartment or are obscured by autofluorescence.